Start by unplugging the mouse from your computer and removing any batteries. Stickiness and dust can lead to a stiff mouse that just doesn’t work as you want it to. Mechanical mice are more susceptible to dust particles that can get caught inside. Optical mice, which use light to detect surface area, require no internal cleaning-but the outside can get sticky over time.
If you use an external mouse, you might want to give it a little love, too.
If you want to wipe in a wax on, wax off motion, that's fine, but don't get overzealous with your scrubbing.